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30, 14351442 10.1007/s00299-011-1052-8 [DOI] [PubMed] [Google Scholar] Logemann E., Hahlbrock K

The advent of personalized and engineered probiotics introduces further complexity, as factors such as individual microbiome variability, host genetics, and polypharmacy can influence both the efficacy and safety profiles, thereby complicating standardized evaluation (527, 528)

Although there are several pharmacological and non-pharmacological approaches for the treatment of migraines, evidence documented several side effects for these medications (16, 17)